AMOXSAN

Capsul            :each capsule contains Amoxicilin trihydrate equivalent to 250 mg/500mg of Amoxicillin.

Dry syrup      : When dispersed with dringking water,each 5 ml contains Amoxicillin Trihydrate equivalent to 125 mg/250 mg of Amoxicillin.

Pediatric Drop : When dispersed with dringking water, each ml contains Amoxicillin Trihydrate equivalent to 100mg of Amoxicillin.

PHARMACOLOGY
Amoxicillin is a derivative of semisynthetic penicillin which is acid stable.Its bactericidal activity is smilar to that of ampicillin.
Amoxicillin is rapidly and well absorbed from the gastrointestinal tract, irrespective of the presence of food, givinga high blood level after one hour. Its absorption is better that that of ampicillin.
Amoxicillin is mainly excreted though the kindneys, in the urine Amoxicillin is recovered in active form.
Amoxicillin is effective against Gram-positive and Gram negative organisms.
Among those bacterial which are sensitive to Amoxicillin are :
- Staphylococcus             

- Steptococcus                             

- Diplococcus pheumoniae 

- Bacillus anthracis                   

- Enterococcus                          

- Corynebateriumdiphtheriae

- Salmonella sp

- M.meningitidis

- Proteus mirabili

- Shigella sp
- H. Influenzae
- E.Coli
- N.gonorrhoeae

INDICATIONS

-Respiratory tract infections:

Tonsillitis,sinusitis,laryngitis,pharyngitis,otitis media,bronchitis,bronshiectasis,pneumonia

-Genitourinary tract infections :

Pyelonephritis,cystitis,urethritis,gonorrhoea.

-Skin and soft tissue infections :

Wounds,cellulitis,furunculosis,pyoderma.

DOSAGES

-Moderate infection

* Adults and children > 20 kg: 250 mg - 500 mg every 8 hours.

* Children with body weight of < 20 kg: 20 - 40 mg/kg body weight/day in divided doses every 8 hours.

- for more severe infections higher doses may be given.

-For patients receiving  peritoneal dialysis,recommended maximum dose is 500 mg / day.

- For treatment of Gonococcus urethritis: 3000 mg as a single dose.

- Dyr syrup is recommended for children > 8 kg: 125 mg - 250mg every 8 hours.

- Pediatric drop are recommended for children under six months of age.

Usually dosage for all indication except infections of the lower respiratory tract:

< 6 kg  : 0,25 ml - 0,50 ml every 8 hours

6 - 8 kg : 0,50 ml - 1,0 ml every 8 hours.

Infections of the lower respiratory tract:

< 6kg  :0,50 ml - 1,0 ml every 8 hours.

6 - 8 kg : 1,0 ml - 1,5 ml every 8hours.